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Adequate stomach acid is required to release the vitamin from the protein, and a substance called intrinsic factor is necessary to ensure its absorption

doi: 10.1016/j.msec.2015.09.025

Simon A, Bontemps Y, Hornebeck W, Maquart FX

In case the participant had not reached at least the first sleep stage 30 min after the administration of the first drug, the second drug was chosen: the participants who received Dex as the first drug received Mel as the second drug, and those who received Mel as the first drug were given Dex (route of administration was again randomly chosen)

Thus, the complex and cell-specific roles of HIF render it difficult to predict the net effect of HIF-PHIs in vivo , and detailed research should be carried out under each condition